abstract |
THERAPEUTICALLY ACTIVE COMPOUNDS UTILIZABLE AS ATARACTIC AGENTS AND AS SEDATIVES AND HYPOTENSIVE AGENTS HAVING THE FORMULA X-(CH(-R))N<(-(R3-1,2-PHENYLENE)-N(-(CH2)R-N(-R2)(-C(=NH)- NH-R1))-(CH(-R))M-(R4-1,2-PHENYLENE)-(CH(-R))P-) WHEREIN R, R1 AND R2 ARE HYDROGEN, LOWER ALKYL, PHENYL OR PHENYL-LOWER ALKYL; R3 AND R4 ARE HYDROGEN, HALOGEN, LOWER ALKYL, TRIFLUOROMETHYL, LOWER ALKOXY; X IS OXYGEN OR SULFUR, R IS 2 TO 5; M IS 0 OR 1; N AND P ARE EACH 0,1 OR 2; PROVIDED THAT THE SUM OF M+N+P BEING FROM 1 TO 3, AND THAT WHEN M EQUALS 1 AND N AND P ARE EACH 0, X IS SULFUR. |