abstract |
N-TRITYL-IMIDAZOLES AND SALTS THEREOF OF THE FORMULA: 1-(((X)N-PHENYL)-C(-(1,4-PHENYLENE)-(X")N")(-(1,4- PHENYLENE)-(X'')N'')-),2-R,4-R1,5-R2-IMIDAZOLE WHEREIN R, R1 AND R2 ARE HYDROGEN, LOWER ALKYL OR PHENYL, OR R1 AND R2 TOGETHER FORM AN ANELLATED BENZENE RING, X, X'' AND X" ARE ALKYL OF 1 TO 12 CARBON ATOMS OR AN ELECTRO-NEGATIVE MOIETY, AND N, N'' AND N" ARE AN INTEGER FROM 0 TO 2, OR PHARMACEUTICALLY ACCEPTABLE ACID SALTS THEREOF MAY BE PRODUCED BY REACTING A SILVER SALT OR ALKALI METAL SALT OF AN IMIDAZOLE OF THE FORMULA: 2-R,4-R1,5-R2-IMIDAZOLE WITH A TRITYL HALIDE OF THE FORMULA: (((X)N-PHENYL)-C(-HAL)(-(1,4-PHENYLENE)-(X")N")-),(X'')N''- BENZENE WHEREIN THE SUBSTITUENTS ARE AS ABOVE DEFINED AND HAL IS HALOGEN. THESE COMPOUNDS ARE USEFUL AS ANTIMYCOTICS. |