abstract |
BENZENESULFONYL UREA COMPOUNDS THAT ARE EFFECTIVE AS ORAL ANTIDIABETIC AGENTS ARE DISCLOSED TO HAVE THE FORMULA 1-(X-N(-X1)-CO-NH-Y-),4-(R-HN-CO-HN-O2S-)BENZENE WHEREIN R IS (A) ALKYL OR ALKENYL OF 3-6 CARBON ATOMS, (B) ENDOALKYLENE-CYCLOHEXYL, ENDOALKYLENE-CYCLOHEXENYL, ENDOALKYLENE-CYCLOHEXYLMETHYL OR ENDOALYLENE-CYCLOHEXENYLMETHYL OF 1-2 ENDOALKYLENE CARBON ATOMS, (C) BENZYL, PHENYLETHYL, (D) CYCLOHEXYL METHY, (E) LOWER ALKYL CYCLOHEXYL OR DIALKYL CYCLOHEXYL METHYL CYCLOPENTYL, (F) CYCLOALKYL OF 5-8 CARBON ATOMS IN THE RING (G) CYCLOHEXENYL, CYCLOHEXENYL-METHYL, METHYLCYCLOHEXENYL OR (H) NORTRICYCLYL, X IS (A) PHENYL, TRIFLUOROMETHYL PHENYL SUBSTITUTED BY ONE TO TWO SUBSTITUENTS SELECTED FROM THE GROUP CONSISTING OF HALOGEN, LOWER ALKYL AND LOWER ALKOXY OR (B) BENZYL, X1 IS ALKYL OF 1 TO 3 CARBON ATOMS, AND Y IS A SATURATED HYDROCARBON OF 1 TO 3 CARBON ATOMS. |