abstract |
CERTAIN 7-(A-(2-,6-DIHALO-4-PYRIDYLTHIO)ACETAMIDO)CEPHALOSPORANIC ACIDS AND DERIVATIVES THEREOF HAVE SHOWN PRONOUNCED ANTIBACTERIAL ACTIVITY AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA AN IN PARTICULAR THE ACIDFAST BACTERIA, MYCOBACTERIUM TUBERCULOSIS H37RV. A PREFERRED COMPOUND, 7-A-(2,6-DICHLORO-4-PYRIDYLTHIO)ACETAMIDO)CEPHALOSPORANIC ACID IS PREPARED BY THE CONDENSATION OF 2,6-DICHLORO-4-MERCAPTOYRIDINE WITH 7-(A-BROMOACETAMIDO) CEPHALOSPORANIC ACID. |