abstract |
A MULT-STAGE PROCESS FOR THE PREPARATION OF COMPOUNDS OF THE GENERAL FORMULA: R3-NH-CH(-R1)-CH(-OH)-),1-(HO-),2-(CH3-)BENZENE IS DISCLOSED FROM THE PARENT KETONE OF THE FORMULA (HO-),(R1-CH2-CO-)BENZENE BY STEPS INCLUDING CHLOROMETHYLATION, ACETYLATION, BROMINATION, AMINATION WITH A COMPOUND OF THE FORMULA PH-CH2-NH-R3 DEACETYLATION AND REDUCTION. THE PRODUCT MAY BE ISOLATED AS A PHARMACEUTICALLY ACCEPTABLE SALT. |