| abstract |
NOVEL ANTIMITOTICALLY EFFECTIVE HALOCOLCHICINE COMPOUNDS OF THE FORMULA 1,2,3-TRI(CH3-O-),7-(R1-NH-),9-(O=),10-R2-5,6,7,9-TETRA HYDROBENZO(A)HEPTALENE WHEREIN R1 REPRESENTS A MONO-, DI- OR TRIHALOACYL RESIDUE OF 2-4 CARBON ATOMS; R2 REPRESENTS -O-CH3, -N(-R3)-R4, -S-CH3, -SO-CH3, OR -SO2-CH3 R3 IS CH3ORC2H5; AND R4 IS H,CH3 OR C2H5. |