abstract |
DIGUANYLHYDRAZONES OF DIPHENYL-UREAS, -THIOUREAS, -GUANIDINES AND -PARABANIC ACIDS THAT CONTAIN IN EACH OF THE TWO PHENYL RADICALS A META- OR PARA-POSITIONED ALKANECARBONYL GROUP, ABOVE ALL CORRESPOINDING DIPHENYL-UREAS, -THIOUREAS, -GUANIDINES AND -PARABANIC ACIDS THAT CONTAIN IN EACH PHYNYL RADICAL A META- OR PARA-POSITIONED ALKANECARBONYL-GUANYLHYDRAZONE GROUPING OF THE FORMULA G-N=C(-R)- IN WHICH G REPRESENTS A GUANIDINO GROUP AND R A LOWER ALKYL RADICAL PREFERABLY A METHYL, EHTYL, PROPYL, BUTYL OR PENTYL RADICAL, AND THEIR SALTS. THESE COMPOUNDS MAY CONTAIN FURTHER SUBSTITUENTS. THEY POSSESS TUMOUR INHIBITING ACTION AND ACT AGAINST PROTOZOAE AND AMOEBAE, ESPECIALLY AGAINST TRYPANOSOMES, FOR EXAMPLE, AGAINST TRYPANOSOMA GAMBIENSE AND TRYPANOSOMA CONGOLENSE. |