abstract |
NEW 183-AMINOETHER OF THE FORMULA IVA: (R'',R",R"''-PHENYL)-CH(-O-R)-CH<(-CH(-N<(-Z-))-CH2-(CH2)N- CH2-) WHEREIN N HAS THE VALUE OF 1 TO 4, INCLUSIVE, WHEREIN -N<(-Z-) REPRESENTS A HETEROCYLIC AMINO RADICAL CONTAINING FROM 5 TO 10 NUCLEAR ATOMS, INCLUSIVE, WHEREIN R IS AN ALKYL CONTAINING FROM 1 TO 6 CARBON ATOMS, INCLUSIVE, WHEREIN R'', R" AND R"'' ARE SELECTED FROM THE GROUP OF SUBSTITUENTS CONSISTING OF HYDROGEN, HALOGEN, ALKYL AND ALKOXY CONTAINING FROM 1 TO 6 CARBON ATOMS, INCLUSIVE, ARE PREPARED. THE NEW COMPOUNDS OF FORMULA IVA PER SE, AS WELL AS IN THE FORM OF ACID ADDITION SALTS HAVE DIURETIC ACTIVITY AND SOME OF THEM HAVE ANTI-HYPERGLYCEMIC ACTIVITY. COMPOUNDS OF FORMULA IVA ARE THUS USEFUL TO PRODUCE DIURESIS IN MAMMALS AND ALSO ARE USEFUL AS ORAL ANTIDIABETIC AGENTS. |