| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56782b50f83dfdd584c8450d27b0cee1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42f8c05ebba982b49d4b553270d260d5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-1613
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2230-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-3334
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-3327 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-341
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H50-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H50-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H20-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H10-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H20-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H50-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H10-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M1-34 |
| filingDate |
2021-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b392ff8fabe22af8c1d5af94d03a5611
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_373c9991fb7512ca783cdedc55fea402
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58e5040548fb18af8c736c4584f71369
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c51b34402e5b86c8212a20805e3d59a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_653ea112e0fffb962f99c3e2411262c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fb52441f50fac2f295fc813228e84ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6581a147c1a7fa47b2d435540016d405
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a06db66f236989e6360f13298658ca23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3a843d520c0da3d9209f5201b46da5f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33e9b415044b0baa543e773a3cb9db6a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09a13bffff4fc730db610c9d050dd400 |
| publicationDate |
2022-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2022415517-A1 |
| titleOfInvention |
Modified Hemofiltration Method for Clearing Peripheral ?-synuclein Aggregates in Patient with Neurodegenerative Disease |
| abstract |
A modified hemofiltration method for clearing peripheral α-synuclein aggregates in patients with neurodegenerative diseases is provided, which falls into the field of medicine. Specifically, a ratio S of synuclein dimers in blood is obtained; a blood flow velocity and an exchange membrane area for hemofiltration are determined through clinical trial data or historical literature data; hemofiltration is performed by the determined blood flow velocity and exchange membrane area, a calculation model of the ratio S of different synuclein dimers and an exchange membrane aperture D required for hemofiltration is constructed by linear regression; a clearance rate of synuclein dimers can be estimated by setting hemofiltration parameters with the calculation model. It is found that hemofiltration is beneficial to reducing the level of peripheral α-synuclein aggregates in patients with neurodegenerative diseases. Therefore, the calculation model is constructed, which provides scientific data and a new solution for clinically relieving α-synuclein-related toxicity symptoms. |
| priorityDate |
2021-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |