| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76ba102ea9c02b6633d64bf09c5b89a4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B29L2031-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B29K2089-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B29K2105-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B29L2031-7532
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B29K2105-0061 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B29C64-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B29C64-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B33Y70-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B33Y70-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B29C64-118
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B29C64-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B29C64-118
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B33Y70-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-52 |
| filingDate |
2022-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfb3debad8fd2d9788606597c6033e61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4800779cfb7fd8ef228f2a8f3d25b30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e28a511585a0bbfb8b98e44c4696b24d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95a40a98e171173fdbb9870a79a46301 |
| publicationDate |
2022-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2022410470-A1 |
| titleOfInvention |
Cross-linkable microgel composite matrix bath for embedded bioprinting of perfusable tissue constructs |
| abstract |
Described herein are apparatuses, systems, and methods for fabricating tissue constructs, such as by fabricating perfusable tissue constructs by embedding a sacrificial material into a composite matrix yield stress support bath. A composite matrix bath can include a microgel filler and a hydrogel precursor. An extrusion tip can be used for embedded printing of perfusable tissue constructs by disposing sacrificial material into the composite matrix bath while the extrusion tip travels along a predefined course through the composite matrix bath. This sacrificial material can be the printed tissue construct or can be removed to render the matrix bath a perfusable tissue construct. The composite matrix bath can include acellular or cell-laden hydrogels. The sacrificial material can include a salt and a physiological buffer or a non-cytotoxic porogen material. The hydrogel precursor can include at least one of gellan and gelatin. Cross-linking can be carried out chemically, thermally, enzymatically, or physically. |
| priorityDate |
2018-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |