http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022340532-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2403aad8bbbf284fed86d63332054c16 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-26 |
| filingDate | 2020-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7eca55c42a114214b05f77258ef22adc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7fee993f23ed3b93920312fccf7cabe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_939bb85deb56acd250af42e4740b5aa7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cc434042bd4487a78090e1f3304c6dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76859bc4a00452ab33b167fd480eddaf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a11eede3f5042cbfd0ed7265d07b8312 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_185fdd3d798b2e75e7add061f5db4825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c08ee00d67ae6cdbcad7cfbe9d22ded5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_604c3cb15f171db1df948928968c54ec |
| publicationDate | 2022-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2022340532-A1 |
| titleOfInvention | Processes for the preparation of roxadustat and intermediates thereof |
| abstract | The present invention provides new procedure and intermediates for the preparation of Roxadustat (1) comprising: (A) reducing a compound of formula 3′, 3″ or a mixture thereof: (3′), (3″) wherein Pg is H or a OH protecting group, Ri is alkyl, aryl, or arylalkyl; R2, R3, R4, and Rs each independently represents alkyl, arylalkyl or alkenyl, or R2 and R3 and/or R4 and Rs, taken together with the nitrogen atom to which they are bonded, each independently form a ring selected from: (I), wherein R6 is H or CI-6 alkyl; R7 is Ci to C6 alkyl and X— is an anion selected from the group consisting of halide, O—SO4—R7 wherein R7 is Ci to C6 alkyl, or O—SO2-Rs wherein Rs is phenyl, tolyl, methyl or trifluoromethyl; to form a compound of formula (2′) wherein Pg is H or an OH protecting group, Ri is alkyl, aryl, or arylalkyl; and removing the Ri group and where present removing the OH protecting group; or (B) reducing a compound of formula 4′, a compound of formula 4″ or a mixture thereof: (4′), (4″) wherein Pg is H or an OH protecting group; Ri is H, alkyl, aryl, or arylalkyl; R2, R3, R4, and R5 each independently represents alkyl, aryl, arylalkyl or alkenyl; or R2 is Ci-4 alkyl and R3 is Ci-4 alkoxy; or R2 and R3 and/or R4 and R5, taken together with the nitrogen atom to which they are bonded, each independently form a group selected from: (I) wherein R6 is H or CI-6 alkyl; and where Ri is not H, removing the Ri group, and, where present removing the OH protecting group. |
| priorityDate | 2019-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 218.