| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_912ae091c561b5ccb9ba99e4788a84dd |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-998
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-952 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-24069
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-99008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0693
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-33 |
| filingDate |
2020-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d629e021caab1c11ba33f9ba439863be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcde25a09d3520003fcca79103a837d9 |
| publicationDate |
2022-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2022326221-A1 |
| titleOfInvention |
Cells Highly Sensitive to Clostridial Neurotoxin |
| abstract |
A method for making a population of cells that are highly sensitive to clostridial neurotoxin, the method comprising: (a) contacting recombinant cells that express an indicator protein with clostridial neurotoxin; and (b) following such contact, selecting the cells that exhibit cleavage of the indicator protein. A cell from the population produced using the aforementioned method. An assay for determining the activity of a modified or recombinant neurotoxin comprising contacting such a cell with the modified or recombinant neurotoxin under conditions and for a period of time sufficient to allow the protease domain of a wild-type clostridial neurotoxin to cleave the indicator protein in the cell and determining the presence of product resulting from the cleavage of the indicator protein. |
| priorityDate |
2019-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |