| abstract |
Disclosed is a new use of a phenothiazine compound in pharmacy, particularly in the preparation of a PD-1 signaling inhibitor, which is selected from the compounds represented by formula (I), their hydrates, solvates and reduced forms. The phenothiazine compounds disclosed herein inhibit the function of PD-1 and block the signal transduction of PD-1, so that they can be used as PD-1 signal transduction inhibitors. In vitro experiments found that these compounds can restore the function of immune cells inhibited by PD-1, thereby improving the function of CTL and other immune cells to secrete cytokines and kill target cells, enhancing the body's immune function and being effective in treating tumor. |