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filingDate 2020-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b1e4880f83bc5fbf7c934641a369103
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publicationDate 2022-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2022298238-A1
titleOfInvention Non-opioid compositions and therapies for pain management
abstract A composition for treating pain includes an antibody or antibody fragment that specifically binds to a receptor involved in pain. In some embodiments, the receptor is a P2X family receptor such as, for example, P2X4. In some embodiments, the antibody includes a detectable marker. In some of these embodiments, the detectable marker includes a fluorescent tag. The composition may be used to treat acute or chronic pain in a subject. Generally, the methods includes administering to the subject a composition that includes an antibody or antibody fragment that specifically binds to a receptor involved in pain. The non-opioid pain relief composition can reverse pain related mechanical, cold, anxiety-like, and depression-like behaviors in neuropathic pain and chemotoxic nerve injury models.
priorityDate 2019-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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