| abstract |
The present invention provides substituted pyrazolo[1,3,5] triaziric and pyrazolo[1,5a] pyrimidine derivatives of formula (I), which are therapeutically useful, particularly as selective transcriptional CDK inhibitors including CDK7, CDK9, CDK12, CDK13 and CDK15, more particularly transcriptional CDK7 inhibitors wherein X, ring A, ring B, L1, L2, R1,R2, R3, R4, R6, m, n and p have the meanings given in the specification and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of disease or disorder associated with selective transcriptional CDKs in a mammal. The present invention also provides preparation of the compounds and pharmaccutical formulations comprising at least one of the substituted pyrazolo [1.5-a] [1-3,5] triazine and pyrazolo[1,5-a] pyrimidine derivatives of formula (I) or a pharmaceutically acceptable salt thereof or a stercoisomer liner thereof. |