abstract |
The present invention relates to inhibitors that bind to gasdermin D and inhibit gasdermin D-mediated cell death and inflammation. The inhibitors can be proteinaceous, for example antigen binding proteins or non-proteinaceous, such as aptamers. It is disclosed an antibody that binds to the peptide of SEQ ID NO: 9: KREGSGRFSLPGATC. In one embodiment the inhibitor binds to gasdermin D and inhibits its association with lipids, such as wherein the inhibitor binds to gasdermin D and neutralizes the association of gasdermin D with lipids, optionally wherein the inhibitor binds to gasdermin D and inhibits its association with phosphatidyl inositol 4-phosphate and/or phosphatidyl inositol 4,5-bisphosphate, such as wherein the inhibitor binds to gasdermin D and neutralizes the association of gasdermin D with phosphatidylinositol 4-phosphate and/or phosphatidyl inositol 4,5-bisphosphate. |