| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B30-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-582
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-585
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 |
| filingDate |
2020-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_146e401bf7690f57ad8b7ba9b39f56de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b81d2805c1b56707e23612e0b930b8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd12b1b447da3361094f3faabb3d5b47 |
| publicationDate |
2022-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2022213471-A1 |
| titleOfInvention |
Small molecule screening cellular assay using modified beads |
| abstract |
A method for screening a DNA-encoded library of chemical structures ( 2 ) for activity in a cellular target ( 11 ) wherein the chemical structures ( 2 ) of the library, the corresponding encoding DNA ( 4 ) and, optionally, a chemical probe ( 7/8/9 ) susceptible to the response molecule ( 12 ) are covalently linked to beads ( 1 ); the method comprising providing an incubation medium ( 13 ) or aliquot thereof comprising the cellular target ( 11 ) and exactly one or more than one bead ( 1 ) as defined above, releasing the chemical structures ( 2 ) from the bead(s) ( 1 ) in the incubation medium ( 13 ) or aliquots thereof by cleaving the structure linkers ( 3 ) and incubating the released chemical structures ( 2 ) and the cellular target ( 11 ); and sequencing the encoding DNA present or remaining on the bead(s) ( 1 ). A bead ( 1 ) suited for the method is also provided. |
| priorityDate |
2019-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |