| abstract |
The invention includes compositions and methods of generating a chimpanzee-derived adenovirus serotype AdC6 or AdC7 vector vaccine, wherein an early gene E1 genomic region is deleted, and wherein the nucleic acid sequence further comprises an expression cassette comprising a promoter sequence operably linked to a sequence encoding a heterologous protein, wherein the heterologous protein is at least one HIV protein selected from the group consisting of gp140 and Gag, wherein gp140 is from a Chinese HIV clade selected from the group consisting of B, AE, BC and C, and wherein Gag is from a Chinese HIV clade B. Furthermore, the invention encompasses a pharmaceutical composition for vaccinating a mammal as well as a protein expression system. |