http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022211657-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1ca2fe5a1e9022aa0323cbb48d30f5e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-282 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-282 |
| filingDate | 2020-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24c992a7bbb33628422983d6f560157d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35cda35b36556551276352a20042217f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7a28d96d72cfa3dae78635b6a8c9096 |
| publicationDate | 2022-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2022211657-A1 |
| titleOfInvention | Methods of treating gastrointestinal cancers and tumors thereof using combination therapy |
| abstract | Aspects of the technology described herein are directed to a method of treating gastrointestinal cancer in a subject. This method involves selecting a subject, where the subject (i) has been diagnosed with a gastrointestinal cancer and (ii) has (a) a pathogenic mutation in one or more homologous recombination-DNA damage repair (HR-DDR) pathway genes and/or (b) a family history suggestive of a breast or ovarian cancer syndrome; and administering to the subject an effective amount of a Poly(ADP ribose) polymerase (PARP) inhibitor, in combination with oxaliplatin and an antimetabolite. Methods of treating a gastrointestinal tumor in a subject and of increasing sensitivity of gastrointestinal tumor cells to oxaliplatin are also disclosed. |
| priorityDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 881.