| abstract |
Disclosed are nanoemulsions comprising puerarin and methods of their use in treating cancer, including breast cancer and melanoma. The presently disclosed puerarin-containing nanoemulsions regulate the tumor microenvironment and importantly de-activate tumor associated fibroblasts (TAFs) rather than killing them. The presently disclosed methods can be used in combination with chemotherapy, e.g., polymer formulations of paclitaxel, or PD-L1 blockade therapy to treat cancer. |