| abstract |
A compound of formula (I) R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2, a stereoisomer and/or cosmetically acceptable salt thereof, and a method of treatment using the compound are described. In the compound, AA1 is Asp, Gly, Asn, Gln, Ala or no amino acid; AA2 is Val, Ile, Leu or Ala; AA3 is Tyr, Phe, Trp, Lys, Arg or His; AA4 is Lys, Arg, His, Pro or Val; AA5 is Asn, Asp, Gln or no amino acid; AA6 is Thr, Ala, Ser or no amino acid. The compounds are useful for the treatment of the symptoms of skin aging and, in particular, for the treatment of skin wrinkles, the treatment of a sagging appearance of the skin, and/or the reduction of facial asymmetry. |