| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bc5292a07e34d16eb1d033a16d3aec3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-25 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-981
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-0216
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0633
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q11-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate |
2020-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4402dc592abcb2e07c150162d263e23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ea9607f936b1fe67f404c5efbac73ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3216a73d5c7af2639246d88964b32d03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbd446b3a523a908812760aa4cec0b85 |
| publicationDate |
2022-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2022175847-A1 |
| titleOfInvention |
Salivary Gland Cell Sheets and Methods for their Production and Use |
| abstract |
The disclosure provides a salivary gland (SG) cell sheet comprising one or more layers of confluent SG cells (e.g. submandibular gland (SMG) cells). Methods of treating a wound in a salivary gland (SG), treating hyposalivation, and treating irradiation damage in an SG are also provided. The disclosure also provides a method for producing SG cell sheets comprising culturing SG cells in culture solution on a temperature-responsive polymer which has been coated onto a substrate surface of a cell culture support, wherein the temperature-responsive polymer has a lower critical solution temperature in water of 0-80° C.; adjusting the temperature of el the culture solution to below the lower critical solution temperature, whereby the substrate surface is made hydrophilic and adhesion of the cell sheet to the surface is weakened; and detaching the cell sheet from the culture support. |
| priorityDate |
2019-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |