http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022162669-A1

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filingDate 2022-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_266a8dd1489433f03ea476b9b733aed0
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publicationDate 2022-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2022162669-A1
titleOfInvention DNA-Antigen Exchange and Amplification
abstract Methods for imaging are described, including, but not limited to a method comprising: (1) contacting a sample being tested for the presence of one or more targets with one or more target-specific binding partners, wherein each target-specific binding partner is linked to a docking strand, and wherein target-specific binding partners of different specificity are linked to different docking strands, (2) optionally removing unbound target-specific binding partners, (3) contacting the sample with antigen-bound imager strands and antigen-specific binding partners linked (directly or indirectly) to optical labels, wherein the antigen-bound imager strands have complementarity to a docking strand, directly or indirectly, and wherein each antigen-specific binding partner is linked to one or more optical labels, and wherein antigen-specific binding partners of different specificity are linked to distinct optical labels, (4) optionally removing unbound antigen-bound imager strands and/or antigen-specific binding partners, (5) imaging the sample to detect bound labeled antigen-specific binding partners, (6) optionally removing/extinguishing signal from the optical labels, and (7) optionally repeating steps (1)-(6), or any subset thereof.
priorityDate 2017-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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