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filingDate 2021-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2022156930-A1
titleOfInvention Cancer risk stratification based on histopathological tissue slide analysis
abstract The subject disclosure presents systems and computer-implemented methods for providing reliable risk stratification for early-stage cancer patients by predicting a recurrence risk of the patient and to categorize the patient into a high or low risk group. A series of slides depicting serial sections of cancerous tissue are automatically analyzed by a digital pathology system, a score for the sections is calculated, and a Cox proportional hazards regression model is used to stratify the patient into a low or high risk group. The Cox proportional hazards regression model may be used to determine a whole-slide scoring algorithm based on training data comprising survival data for a plurality of patients and their respective tissue sections. The coefficients may differ based on different types of image analysis operations applied to either whole-tumor regions or specified regions within a slide.
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