| abstract |
This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R 1 is hydrogen, chloro, methyl or methoxy, R 2 is hydrogen or methoxy, with the proviso that at least one of R 1 and R 2 is other than hydrogen, G 1 represents chloro, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH 2 —OR 3 , —CH 2 —NR 4 R 5 or —C(=0)-NR 4 R 6 , and G 2 represents chloro, cyano, (C 1 -C 4 )-alkyl, or the group —CR 8A R 8B —OH, —CH 2 —NR 9 R 10 , —C(=0)—NR 11 R 12 or —CH 2 —OR 15 , having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases. |