| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d94573ab2c57e8b193f3a22accddf9fe |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-177
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-45 |
| filingDate |
2022-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4383ca1d04a210b154ef8e9e34098f39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_954f261bb3edb7be5343bcfd0e03db49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c6a9e4bed96f9f7c5fa9923862a76b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9d0b0c1ad3abfeb339a072d173e5454 |
| publicationDate |
2022-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2022125877-A1 |
| titleOfInvention |
Method for treating colorectal cancer |
| abstract |
The present invention relates to a method for treating colorectal cancer (CRC); this present invention confirms that KRAS mutation CRC patients benefit from metformin more significantly for the first time and further confirms that the down-regulated expression of MATE1 in the discharge passage of metformin is a key mechanism for the sensitivity of KRAS mutation CRC cells to metformin. The transcriptional level of MATE1 is decreased and the concentration of metformin in tumor cells is increased by upregulating the transmethylase DNMT1 and down-regulating the demethylase TET1/2, and thereby the inhibiting effect of metformin on tumor cell proliferation is enhanced. The present invention provides a novel thinking and method for the treatment of colorectal cancer, which has profound significance and is worth popularizing energetically. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116004835-A |
| priorityDate |
2019-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |