http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022119408-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ea17ba87480b776cce77451f86b25bb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-12 |
| filingDate | 2020-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0120af1ca00467a53765d923d5b98b38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85b8e431518a773cacb6523f7b8a2a15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2d54108e29e0c0d7bc12dfa6f87a846 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b42d38654d30b440cfe781c3bb1be6a |
| publicationDate | 2022-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2022119408-A1 |
| titleOfInvention | Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof |
| abstract | The invention discloses a process for the preparation of maytansinoid esters of formula (I) comprising a thiol or disulphide group wherein R1, R4 and R5 and the asterisk are as defined in the description, by reacting maytansinol with an enantiopure alpha-azido acid, followed by reduction of the azido group and reacting the obtained amino-ester with a compound of formula (IX) (IX) R3—S—S—X—COOH wherein X and R3 are as defined in the description, or with a reactive derivative thereof and optionally reducing the obtained disulfide-containing maytansinoid ester to give a maytansinoid ester wherein R1 is a —X—SH group. |
| priorityDate | 2019-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 162.