abstract |
Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder:whereinR1 is methyl or ethyl;R2 is selected from methyl, ethyl, methoxy and ethoxy;R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl;R4 is selected from methyl, ethyl and βCH2OCH3;R5 and R6 are each individually methyl or hydrogen; andR7 is selected from methyl, ethyl, β(CH2)2OH and β(CH2)2OCH3, or a pharmaceutically acceptable salt thereof. |