http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022112168-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee898d21893bd1a3474a17e2d8502894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-42 |
| filingDate | 2021-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0926fb8bfce2bb26e43ede0cd969c8ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af48bb5f83dcb7e24a25636628394d01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1353f8836fcd612187842ef5a888bf60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d411371c31abec8da9cf2681451590b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0f241b9d06f413ec5c6f0b952efd7e5 |
| publicationDate | 2022-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2022112168-A1 |
| titleOfInvention | Environment-friendly preparation method of a substituted oxazole compound |
| abstract | N-substituted formyl-alpha-substituted glycine ester is used as the initial raw material, a cyclization reaction is performed under the action of a dehydrating agent (trisubstituted phosphine dihalide, a combination of trisubstituted phosphine dihalide and an acyl halide reagent, or a combination of trisubstituted phosphine oxide and an acyl halide reagent) and an organic amine to obtain the substituted oxazole compound, and the resulting substituted oxazole compound can be further saponified and de-carboxylated to obtain a medical intermediate 4-substituent-5-substituent oxy-oxazole; the reaction process can be carried out in a continuous flow mode to improve the productivity and reduce operations; the byproduct trisubstituted phosphine oxide in the reaction process can be repeatedly used to reduce the cost; dehydrating agents (phosphorus oxychloride and phosphorus pentoxide). |
| priorityDate | 2020-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 150.