http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022099666-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_430cacf99ddb7f605e0f2da544a3f477 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4724 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B50-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B50-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 |
| filingDate | 2021-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38b8afe6abb422368c949ce1507bc01e |
| publicationDate | 2022-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2022099666-A1 |
| titleOfInvention | Multivalent glycan microarray platform |
| abstract | The present invention includes a multivalent glycan microarray for detection of glycan-binding proteins. The multivalent glycan microarray allows a multivalent presentation of glycan on a microarray substrate, which can enhance binding of the glycan binding protein to the glycan microarray. The multivalent microarray includes a solid substrate having one or more branched polymers bonded to it via one or more silane-based linker reagents. The branched polymer in turn is bonded to a glycan, via one or more bifunctional linkers to form the multivalent glycan microarray. Nonspecific binding of glycan binding proteins to the multivalent glycan microarray can be reduced by using a blocking reagent coated on to the microarray substrate, which includes a polyethylene glycol surfactant attached to the solid substrate via a self-crosslinking azido-functionalized silane. Methods for making multivalent glycan microarrays and methods for using same to detect glycan-binding proteins are also disclosed. |
| priorityDate | 2016-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 112.