| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_faafbacd692f8f584c47fcca402df63a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be0498c77b6a010db02ad7594cb9b9ba |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3183
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-531
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-16 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115 |
| filingDate |
2020-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5189c62c70986870b828bb6a326205c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a80226ae55380777b786f55e24994db8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92043b63677ad476005219285192e111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b11b49ed5591b1013e0e4fc8ba21bc5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_186e5bcc7a03b1962bf27697aea89dae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f372a8d8d3fa9a410bc690f347c2bab5 |
| publicationDate |
2022-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2022098591-A1 |
| titleOfInvention |
Stem-loop compositions and methods for inhibiting vascular endothelial growtn factor |
| abstract |
The application discloses methods and compositions for inhibiting functions associated with vascular endothelial growth factor-A (VEGF-A). The methods and compositions may involve the use of pan-variant specific aptamers for binding to VEGF-A, and preventing or reducing association of VEGF-A with Flt-1, KDR, or Nrp-1. The methods and compositions may include one or more aptamers that bind to receptor binding face of VEGF-A. The methods and compositions may include one or more aptamers that bind to a receptor binding domain of VEGF-A. The application further provides anti-VEGF-A aptamers for the treatment of ocular diseases or disorders. In some cases, the anti-VEGF-A aptamers may have a stem-loop secondary structure. |
| priorityDate |
2019-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |