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filingDate 2021-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2022090134-A1
titleOfInvention Enhancing Immunity Using Chimeric CD40 Ligand and Coronavirus Vaccine
abstract The present disclosure provides methods and compositions for enhancing immunity by administering a coronavirus vaccine and a chimeric CD40L polypeptide. The coronavirus vaccine can be comprised of inactivated coronaviral particles or an antigenic polypeptide, preferably the coronavirus spike protein. The coronavirus antigenic polypeptide can be a purified antigenic polypeptide or a nucleic acid expression construct that encodes the antigenic polypeptide. The chimeric CD40L polypeptide in compositions of the invention can be a purified chimeric CD40L polypeptide or a nucleic acid expression construction that encodes the chimeric CD40L polypeptide.
priorityDate 2020-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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