| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba691e6c807a1a62a286bfc83e5b4ba9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_066af93d226b9a8b1151cb1bc45bd190 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0239
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C247-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 |
| filingDate |
2019-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c51f273bcfb0cc85367724140fb78f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4ddace54c3e57e2aee8a6e2beb8e297
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b1a94a5375cc9b8abf68595f0591fc7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1aa282d5db8ce28b9b7bc085cf4d85f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a1e61318b43798739c52888d89741d4 |
| publicationDate |
2022-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2022089526-A1 |
| titleOfInvention |
Synthesis Method for Candesartan Cilexetil Intermediate |
| abstract |
A synthesis method for a candesartan cilexetil intermediate represented by formula (II) is provided. The method includes (1) dissolving a compound represented by formula (IV) to an aprotic solvent to obtain a first mixed solution, and dissolving a phase transfer catalyst and an azidation reagent to water to obtain a second mixed solution; (2) dropping the first mixed solution to the second mixed solution for azidation reaction, and after the reaction is ended, standing and layering same to obtain an organic phase containing a compound represented by formula (V); (3) dropping the obtained organic phase containing the compound represented by formula (V) to tertiary butyl alcohol for rearrangement reaction, and after the reaction is ended, concentrating same to obtain a solid or oily material, then adding a crystallizing solvent to the obtained solid or oily material for recrystallization, and separating same to obtain a crystal. |
| priorityDate |
2019-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |