| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b603ecd95b3b1497ae9f30752a676c0e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate |
2019-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_924d002ceb2250588716b9790e8db5dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_535dd5a89939012c7c1db45dfaa6856d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d6fee8adb87c0566e4a23b23ad204b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f16b25f58259de1c92fc3298642fed8e |
| publicationDate |
2022-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2022040183-A1 |
| titleOfInvention |
Use of inhibitors of stress granule formation for targeting the regulation of immune responses |
| abstract |
The mechanisms of tumor escape are numerous, but the immunosuppressive action of coinhibitory molecules has emerged this last decade as the most attractive one for imaging new treatments of cancer. Activation of lymphocytes is indeed regulated by both costimulatory and coinhibitory molecules also called “immune checkpoints”. Now the inventors show that T cell activation triggers mRNA and protein expression of stress granule components and more particularly show that immune checkpoint mRNA interact with said stress granules. More importantly, stress granule inhibitors impair expression of immune checkpoint and thus represent an attractive target for targeting the regulation of immune response. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115920006-A |
| priorityDate |
2018-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |