http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022025331-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-70 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0655 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077 |
| filingDate | 2021-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6921b9c4afc468f035241c911711f522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a334d9afe79a0e18288c54fa246bfb3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f6932bb3de8b0c61f765efdbe0974d5 |
| publicationDate | 2022-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2022025331-A1 |
| titleOfInvention | Methods and systems for improving cells for use in therapy |
| abstract | Methods and systems for enhancing cell populations such as chondrocytes for tissue engineering applications, e.g., for production of neocartilage. The methods and systems of the present invention feature the introduction of a hypotonic buffer to the cells during the cell isolation process, which results in neotissue (e.g., neocartilage) constructs that are significantly more mechanically robust as compared to those not treated with hypotonic buffer. The methods and systems may further comprise introducing cytochalasin D to cells purified with a hypotonic buffer, which can further bolster the mechanical properties and matrix deposition of the cells. The methods and systems result in neocartilage engineered from chondrocytes, for example, from fetal aged tissue, having compressive properties on par with native adult articular cartilage. |
| priorityDate | 2017-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 242.