| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_02d2b7b5831d88d46035d44c54256fb0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4468 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-98 |
| filingDate |
2021-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f1b2c1ad239b52882a0b76fd769ffe5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e07afe0838e0e12db23375520a450714
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b595323ace5648bc088909291fedd837
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31dd1638587fc069c25d2cd06c15b3c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_433aa6647f9933cfa5a3ded3578d4130
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_908a07e1f7e787b01187f3edc60994c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b47fa0d85861b8b058503bfa7ce49110 |
| publicationDate |
2022-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2022024871-A1 |
| titleOfInvention |
Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c |
| abstract |
Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is —OR i or —NR 2a R 2b ; R 3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R 4 is substituted or unsubstituted aralkyl; X is —OR 22 or —NR 23 R 24 ; (wherein R 22 is hydrogen or substituted or unsubstituted C 1-6 alkyl and one of R 23 and R 24 is hydrogen and the other is hydrogen or N-methylpiperidin-4-yl); and R 21 is —OCH 2 CH(CH 3 ) 2 or F; Also disclosed herein is the tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11452721-B2 |
| priorityDate |
2015-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |