| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d10550be2af1509d6eafc5f5f46f844c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-78 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1089
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B50-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B10-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40 |
| filingDate |
2019-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c902869fac272b6ab35f2ea98bb20d45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c44aeb0964c4e920bcb2a7c01fb95e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cc47e611d9fb2801d63765486fc7771
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29a5e0227b10eafd2ccb1af0070777bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3b9d8a371218017f829aeb497cafac8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76c53e8c6c95373a5713ff6e9a57c6f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed99164a25dbc4180b4485bdcbf04e76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_506f98def42feeb05f2400779d12a0e4 |
| publicationDate |
2021-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2021388063-A1 |
| titleOfInvention |
Antibody Library and Method |
| abstract |
This disclosure relates to methods of generating antibody libraries, antibody libraries produced using such methods, and variant antibodies. Presently, methods of improving antibody binding (affinity maturation assays) require the screening of vast libraries of antibody variants (often >10 10 ) to identify a small fraction of variants with improved characteristics. The present invention involves taking the nucleotide sequence of the framework and complementarity determining region of a target antibody and identifying motifs which would be recognised by deamination somatic hypermutation enzymes. A small library of variants is then created which incorporate one or more of these mutations. It was found that a relatively high proportion of the variants have an increased affinity. The technique of the present invention was demonstrated on the trastuzumab and Cathepsin S antibodies, and the variants produced are also claimed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110382696-A |
| priorityDate |
2018-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |