| abstract |
A group of chimeric antigen receptors (CARs) having two, three or four CAR molecules,wherein the members of the group of CARs can be different in their amino acid sequences, andwherein each of the CAR molecules of the group includes at least a transmembrane domain and an ectodomain comprising either an antigen binding moiety or a binding site to which another polypeptide is able to bind, wherein the polypeptide comprises an antigen binding moiety;wherein each CAR molecule of the group includes at least one dimerization domain, wherein this dimerization of a pair of dimerization domains is either induced by a regulating molecule and optionally reduced by another regulating molecule, or occurs in the absence of a regulating molecule and is reduced by a regulating molecule, andwherein the antigen binding moieties of the CAR molecules of the group specific for one target antigen. |