| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20f6ff89c977dfc2930c2abc46f4f307
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7e53e0e2bc34d89e233d19f0496334d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c5969d54d5188258a73033a0242d19c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-149
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-1488
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-1402
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2821 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N15-1459
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N15-1429
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1093
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-50 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N15-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2021-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e48ad780ad86031ba40abb0a1b67cc05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f54e7b42183c5a8d099cd6295054dc8e |
| publicationDate |
2021-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2021349077-A1 |
| titleOfInvention |
Method of quantifying induced membrane permeability and of screening compounds able to prevent said permeability |
| abstract |
The present invention provides the method to quantify membrane permeability induced by various treatments including the formation of membrane pores/channels. Membrane channels created by misfolded (amyloidogenic) proteins are involved into development of various diseases, for which there is no known treatment, such as Alzheimer's disease, Amyotrophic Lateral Sclerosis, diabetes. The invention embodiments include methods to screen chemical entities for the ability to prevent increased membrane permeability. Finding chemical entities, which can prevent functioning of membrane channels formed by amyloidogenic peptides, is one of ways to develop treatments for said diseases. The invention embodiments can be used to observe the dynamics of formation of channels in biological or chemical systems where the channels are produced over time, for example to monitor channel formation by peptide fragments formed by proteases digesting full-length amyloidogenic peptides. |
| priorityDate |
2020-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |