| abstract |
Disclosed herein is macroporous controlled porosity silica gel (CPSG) covalently modified with a variety of moieties (e.g., moieties suitable for oligonucleotide synthesis comprising a spacer, a linker and a nucleoside, chromophore, ligand or bioconjugation linker, or a spacer and a universal linker). Also disclosed herein are methods of making the covalently-modified, macroporous CPSG, and methods of using the covalently-modified, macroporous CPSG to synthesize oligonucleotides. |