| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc62792656aa2e858252e97e5ffaca79 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B35-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-7028 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B20-00 |
| filingDate |
2021-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_684717909cec9730c5161f36c548dd4c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69ed9ff67f8e10d5d4808c26c4c2fab8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d4833448a4a57d392718f01cc844b26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5599a7a3511387ebb71e83ef6a13d471
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f89c5ed0f2347a2267c4fa5828571224 |
| publicationDate |
2021-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2021317533-A1 |
| titleOfInvention |
Unbiased identification of tumor rejection mediating neoepitopes |
| abstract |
Described herein is an unbiased method of identifying tumor rejection mediating neoepitopes (TRMNs). Putative neoepitopes from a cancer cell exome sequence from a cancer patient are putative neoepitopes are unbiased by MHC binding and/or CD8T* reactivity. By plotting the putative neoepitope IC 50 s on one axis, and the non-mutated amino acid sequence IC 50 s on a perpendicular axis to provide a bivariate scatter plot, novel TRMNs are identified TRMNs the neoepitopes in the bivariate scatter plot which are in the space greater than 501 nM on the x-axis and greater than 501 nM on the y-axis. Peptides and nucleic acids for expressing peptides including the TRMNs are also described. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11338026-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115841488-A |
| priorityDate |
2020-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |