| abstract |
Described herein are lipid nanoparticles (LNPs), comprising neutral or positively charged nucleic acid mimics (NPNAMs) and optionally nucleic acids, and compositions thereof. Also described are methods of preparing LNPs comprising NPNAMs, and methods of use for intracellular gene editing. In particular, the LNPs comprising NPNAMs and optionally nucleic acids may be used in methods for the correction and/or treatment of a genetic disorder, disease, or condition in a subject. |