| abstract |
There is provided a peptide-containing compound that comprises a peptide component which is an amino acid sequence of from 2 to 45 (e.g. from 6 to 15) amino acids, which peptide component is covalently bonded to one or more compounds of the formula I: n n n n n n n n n n wherein: n R 1 is selected from the group consisting of —C(CH 3 ) 2 OH, —COCH 3 , —C(CH 3 )═CH 2 and —C(CH 3 ) 2 H; and n n is 0, 1 or 2, n as well as regioisomers, stereoisomers, and pharmaceutically- or cosmetically-acceptable salts of said peptide-containing compound. The compound of formula I is preferably montelukast, montelukast styrene or hydrogenated montelukast styrene. The peptide-containing compound is particularly useful in the treatment of conditions characterised by inflammation, including wounds, hemorrhoids, burns, psoriasis, acne, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, chronic obstructive pulmonary disease, inflammatory bowel disease (such as. ulcerative colitis). Compounds of the invention are also useful in the treatment of idiopathic pulmonary fibrosis. |