http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021300983-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44952652d54854af6a6af9c3bd65b596 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 |
| filingDate | 2020-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3f0b37efcea594170266574a96a206f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17948c7bbcecb2cd4233f517496b560c |
| publicationDate | 2021-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2021300983-A1 |
| titleOfInvention | Ultra-long acting insulin-fc fusion proteins and methods of use |
| abstract | The present disclosure provides recombinantly manufactured ultra-long acting insulin-Fc fusion proteins for use in treating canine diabetes. The insulin-Fc fusion proteins comprise an insulin polypeptide linked via a peptide linker to an Fc-fragment of canine origin. Based on the results obtained, creating a treatment that is amenable to low cost manufacturing, exhibits sufficient in vivo bioactivity, displays extended duration of bioactivity, does not induce anti-drug antibodies, and substantially retains is potency over multiple administrations, requires a non-obvious combination of insulin polypeptide, peptide linkers, and species-specific Fc fragment, in addition to selective mutations on one or more of these components. Exemplary ultra-long acting insulin-Fc fusion proteins, polynucleotides encoding these insulin-Fc fusion proteins, and pharmaceutical formulations of exemplary insulin-Fc fusion proteins are provided, in addition to methods of use and preparation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11555058-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023086980-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114675019-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11673934-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773151-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11707517-B2 |
| priorityDate | 2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 179.