http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021299193-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-225 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-747 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-105 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-747 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-82 |
| filingDate | 2019-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d994741adcb0f14f7f0a4518b041c677 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1b8ffdbf1544512e39d9672924d178d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d02eb76602bd4bc56a598c1e670a3263 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72c936ddafa60eb263b7b4f66290c058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd02969e94a985b216b7c562e67a116c |
| publicationDate | 2021-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2021299193-A1 |
| titleOfInvention | Synbiotic composition for improving immune response and antioxidant capacity during aging and a process for the preparation thereof |
| abstract | The present invention provides a synbiotic combination of i) a probiotic micro-organism comprising of a Lactobacillus strain, and ii) a catechin component comprising EGCG that acts as a second generation synbiotic with synergistic effects in improving the immune response and antioxidant capacity during aging that may beneficially affect the health of elderly. The catechin fraction exhibited differential effects on growth of bacteria with strong inhibition of pathogenic bacteria as opposed to probiotic bacteria suggesting its prebiotic efficacy. In vitro testing indicated protective effects of catechin and probiotics in a synergistic manner resulting in amelioration of oxidative and inflammatory stress. In vivo analysis in aging animals further indicated that the synbiotic combination could rejuvenate the aging immune system by enhancing cellular immune response with increase in numbers (CD3+ T cells) as well as activation status of cellular immune cells (CD3+ T cells/neutrophils) along with their functional capacity (Th1/Th2 immune response) coupled with a corresponding decrease in humoral immune response (IgA) in intestine suggesting the impact of synbiotics in activating cellular immunity. Further, total antioxidant capacity (in plasma) increased in synbiotic fed animals with increased Nrf2 expression while no unwarranted exacerbation of inflammation (NfkB expression) was observed in liver extracts. Several of the observed effects showed synergism wherein the effect of synbiotics was more pronounced than pure additive effects of individual components. Together, it appears that this novel synbiotic formulation could significantly impact aging physiology and help ameliorate some of the deleterious effects during aging. |
| priorityDate | 2018-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.