| abstract |
The disclosure provides methods and compositions for modulating cellular aging comprising contacting a cell with an inhibitor of USP16. The disclosed methods may be used to improve the efficacy of cell-based therapies, including chimeric antigen receptor (CAR)-T cell therapies, engineered T cell receptor (TCR) therapies, natural killer (NK) cell therapies, hematopoietic stem cell-based therapies, and other adoptive cell therapies. |