http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021276973-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d7e2f8fb5650d7d3616661464b67771 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-4866 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
filingDate | 2019-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49c070d483e9dd31c3f3b8fdb626de8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bbd569bb3c16cbfb6919528b3d9d998 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af58145333348d002e27ccaf8b3804cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8479e16dc7a4f924f378a394e0573e99 |
publicationDate | 2021-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2021276973-A1 |
titleOfInvention | Crystal habit of quinoline derivative and preparation method for crystalline powder thereof |
abstract | The present application relates to the field of pharmaceutical technology, specifically to the crystal habit and crystalline powder preparation of quinoline derivatives, and more specifically, to the crystal habit and crystalline powder preparation of anlotinib dihydrochloride. The compound of formula II disclosed herein is a crystalline powder with a flaky crystal habit having a specific surface area ≥10 m 2 /g and a particle-size distribution of X 50 ≤50 μm and/or X 90 ≤500 μm, such that a large specific surface area is provided without reducing the particle size of the drug by a physical method under the condition of a broad particle-size distribution, and the drug can rapidly dissolving. In addition to excellent dissolution property, the crystalline powder is also beneficial to industrial manufacturing, featuring simplified process and cost-efficiency. |
priorityDate | 2018-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.