| abstract |
Stable and economical methods for producing coenzyme Q10A are described. These methods include concentrating a culture suspension of a coenzyme Q10-producing microorganism efficiently, while minimizing a loss of coenzyme Q10 prior to an extraction step or a homogenization process. The methods for producing coenzyme Q10 may comprise a filtration step of passing a culture suspension of a coenzyme Q10-producing microorganism through a porous membrane in a state where the culture suspension is heated to a heating temperature of 35° C. or higher. In order to improve the average permeation flux, a regenerating step may be performed, preferably at least once, which involves closing a filtration device, applying pressure, and then releasing the pressure; or a regeneration treatment of allowing a medium to flow in from a filtrate outlet side and passing the medium through the porous membrane for a certain time, prior to normal filtration. |