| abstract |
Provided are compounds having SHP2 inhibitory activity, preparation methods and use thereof. Specifically, provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, or enantiomers, diastereoisomers, tautomers, solvates, isotope-substituted derivative, polymorphs, prodrugs or metabolites thereof, wherein the groups are as defined in the description. The compounds have high inhibitory acitivity against SHP2, and thus can be used for preventing or treating SHP2-related diseases. |