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filingDate 2021-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2021-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2021220264-A1
titleOfInvention Dosage form with sustained release melatonin pellets
abstract A composition comprises a therapeutically effective oral pharmaceutical dosage form. The dosage form includes an aqueous carrier material having an acidic pH and a plurality of individual pellets having a first dose of melatonin therein. The individual pellets comprises (i) a solid core; (ii) an active coating over the solid core, the active coating including melatonin and a hydrophilic binder; and (iii) an enteric coating over the active coating. A dissolution pH of the enteric coating is higher than the acidic pH of the aqueous carrier material.
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